Product ISBN : 978-1-78902-010-6
Publishing house: Glimmer Publishing
Number of pages: 67
Author: Sharad Kamble
Year of publication: 2018
In the present study, Gliclazide is a second generation sulfonylurea derivative used to treat non-insulin dependent diabetes mellitus. The drug has been classified as class-II drug according to biopharmaceutical classification system having low solubility and high permeability. So an attempt was made to enhance the solubility of gliclazide by the solvent evaporation technique. A significant enhancement of gliclazide dissolution rate will be obtained using by using suitable techniques. In this PVP-k30, polyethylene glycol and soluplus were mixed with the drug in different ratios (1:1, 1:3) and prepare P1, P2, PE1, PE2, S1, and S2 solid dispersion batches.