Design and Development of Fast Dissolving Tablet of Gliclazide

Design and Development of Fast Dissolving Tablet of Gliclazide
€ 34.1

Series:

Tags: Gliclazide Fast dissolving tablet Solid dispersion Solvent evaporation method

Product ISBN : 978-1-78902-010-6

Publishing house: Glimmer Publishing

Language: English

Number of pages: 67

Author: Sharad Kamble

Year of publication: 2018




In the present study, Gliclazide is a second generation sulfonylurea derivative used to treat non-insulin dependent diabetes mellitus. The drug has been classified as class-II drug according to biopharmaceutical classification system having low solubility and high permeability. So an attempt was made to enhance the solubility of gliclazide by the solvent evaporation technique. A significant enhancement of gliclazide dissolution rate will be obtained using by using suitable techniques. In this PVP-k30, polyethylene glycol and soluplus were mixed with the drug in different ratios (1:1, 1:3) and prepare P1, P2, PE1, PE2, S1, and S2 solid dispersion batches.





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